Pathway details: purine nucleotide metabolism (phosphotransfer and nucleotide modification) (v4.0)


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  Pathway was created on Thu Jul 19, 2007
 General background: Purine nucleotides represent fundamental compounds central to both primary metabolism and many aspects of secondary plant metabolism. They are involved in numerous vital cellular processes which are essential for plant growth and development . |FRAME:PWY-841| is of special importance in meristematic cells as it provides the building blocks for DNA and RNA in those dividing and elongating tissues . Further phosphotransfer and nucleotide modification (this pathway) converts the mono- and dinucleotides to triphosphate nucleotides which serve as universal energy source in plant metabolism, equilibrate different pools of nucleotides and give rise to metabolic pathways such as |FRAME:PYRIDNUCSYN-PWY| , |FRAME:RIBOSYN2-PWY| and |FRAME:PWY-3742| |CITS: [Basset05]|. In addition, purine nucleotides can be degraded in |FRAME:PWY-5044| or recycled in the |FRAME:PWY-5043| to ensure their homeostasis for vital metabolic processes. About the pathway: The purine nucleotide metabolism that comprises phosphotransfer and nucleotide modification routes appears to be tightly regulated but not well understood . The mononucleotides such as AMP and GMP are phosphorylated to form the corresponding dinucleotides by adenylate kinase and guanylate kinase which is also actively employed in the guanine salvage pathway. From there a series of reactions leads to the formation of triphosphate nucleotides and/or their deoxynucleosite derivatives. Nucleoside diphosphate kinases (NDK's) are discussed as housekeeping enzymes that maintain the intracellular levels of (d)NTP's. There are three NDK's found in Arabidopsis thaliana (AtNDPK-1 - 3) from which one of them, i.e. ATNDK-2 has been characterized in more detail . It could be demonstrated that this enzyme is involved in several metabolic events such as the phytochrome mediated growth and developmental processes , auxin regulated processes and cellular redox regulation by interacting with activated mitogen-activated protein kinases (MAPKs) . Ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to deoxyribonucleotides providing the cells with the DNA precursors. RNR's are heterodimers that consist of 2 large (R1) and 2 small (R2) subunits. The large RNR subunit is encoded in Arabidopsis by one gene (At2g21790) whereas the small RNR subunits are encoded by a small gene family of three members |CITS: [Sauge-Merle97]| . - aracyc
First part of this pathway occurs in cytosol and ends in plastids. References: - siva
  Parts of this pathway occur in:   cytosol     plastid     nucleus     mitochondrion  


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polypeptide [27]
protein complex [17]
metabolite [22]
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Copyright Wurtele lab

 

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